Brain aerobic glycolysis functions and Alzheimer’s disease

Regional aerobic glycolysis in the human brain.

Aerobic glycolysis is defined as glucose utilization in excess of that used for oxidative phosphorylation despite sufficient oxygen to completely metabolize glucose to carbon dioxide and water. Aerobic glycolysis is present in the normal human brain at rest and increases locally during increased neuronal activity; yet its many biological functions have received scant attention because of a prev...

Aerobic glycolysis and lymphocyte transformation.

1. The role of enhanced aerobic glycolysis in the transformation of rat thymocytes by concanavalin A has been investigated. Concanavalin A addition doubled [U-(14)C]glucose uptake by rat thymocytes over 3h and caused an equivalent increased incorporation into protein, lipids and RNA. A disproportionately large percentage of the extra glucose taken up was converted into lactate, but concanavalin...

Aerobic Glycolysis: Beyond Proliferation

Aerobic glycolysis has been generally associated with cancer cell proliferation, but fascinating and novel data show that it is also coupled to a series of further cellular functions. In this Mini Review, we will discuss some recent findings to illustrate newly defined roles for this process, in particular in non-malignant cells, supporting the idea that metabolism can be considered as an integ...

The aerobic inhibition of glycolysis associated with brain mitochondria.

The Role of Aerobic Glycolysis in the Resting Human Brain

Transient regional increases in brain activity associated with task performance result in elevated glucose metabolism greater than the corresponding increase in oxygen consumption (aerobic glycolysis). Aerobic glycolysis is also present in the resting adult brain but neither its regional pattern nor its mission is known. We studied the distribution of aerobic glycolysis in the resting human bra...